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DSIP
Delta Sleep-Inducing Peptide — The Original Sleep-Architecture Research Compound
DSIP (Delta Sleep-Inducing Peptide) is a naturally occurring nonapeptide first isolated in 1974 from the cerebral venous blood of rabbits in induced slow-wave sleep. Unlike sedative compounds, DSIP has been studied as a neuromodulator that appears to influence sleep architecture — particularly delta-wave (slow-wave) sleep — as well as stress-hormone regulation, thermoregulation and pain thresholds. It remains one of the longest-studied endogenous peptides in sleep and neuroendocrine research.
- Endogenous nonapeptide isolated in 1974 from slow-wave-sleep brain dialysate
- Studied for delta-wave sleep architecture, cortisol regulation and pain thresholds
- Crosses the blood-brain barrier; five decades of published neuroendocrine literature
5mg per vial · Lyophilized Powder · Ships same business day from Toronto
Questions about this batch? Text an agent at (905) 993-4764
99.1%
HPLC purity
Batch TR-DSIP-2026-001, ISO 17025 verified
9
Amino acids
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
1974
Year isolated
Monnier & Schoenenberger, University of Basel
Research benefits
Sleep Architecture
Studied for increased delta-wave (slow-wave) sleep and reduced sleep-onset latency in animal and early human models
Stress-Axis Modulation
Investigated for normalising corticotropin and cortisol responses under stress conditions
Neuroprotection & Analgesia
Researched for elevated pain thresholds, thermoregulation and opioid-withdrawal models
Study findings
Summaries of published research on this compound. Findings are reported for scientific context only and do not constitute claims about this product.
Isolation and characterisation of DSIP
A humoral factor from the cerebral venous blood of rabbits in slow-wave sleep induced delta-wave sleep when transfused into recipient animals; the nonapeptide was sequenced and named DSIP.
Proceedings of the National Academy of Sciences · 1977
DSIP in chronic insomnia patients
Administration was associated with reduced sleep-onset latency and improved sleep efficiency in a small clinical series of chronic insomniacs.
European Neurology · 1984
Stress-axis and ACTH modulation
DSIP administration attenuated stress-induced corticotropin and corticosterone elevations in rodent models.
Neuroendocrinology · 1986
Analgesic and withdrawal models
DSIP raised pain thresholds and reduced withdrawal symptom severity in opiate- and alcohol-withdrawal animal and clinical pilot models.
Progress in Neuro-Psychopharmacology · 1984
Endogenous DSIP-like immunoreactivity in humans
DSIP-like immunoreactivity was detected in human plasma, cerebrospinal fluid and breast milk, with circadian variation in plasma levels.
Journal of Neurochemistry · 1985
What researchers report
Aggregated, anonymized observations from laboratories ordering this compound. Anecdotal and non-clinical.
Overwhelmingly selected for evening-administration study designs to align with the natural delta-sleep window.
Researchers frequently describe the effect profile in models as non-sedative — sleep architecture shifts rather than sedation onset.
Commonly run alongside GH-secretagogue arms because deep-sleep GH pulses are a shared endpoint.
Short plasma half-life is the most-cited design constraint; timing precision is emphasised in protocols.
Technical specifications
| Form | Lyophilized Powder |
| Sequence | Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu |
| Molecular Weight | 848.81 g/mol |
| Purity | ≥99% |
| Amount | 5mg per vial |
| Storage | Store at -20°C, protect from light |
| Shelf Life | 24 months (stored at -20°C) |
| COA | COA Available → View Lab Results |
Storage & reconstitution
Store lyophilized vial at -20°C, protected from light.
Reconstitute with bacteriostatic water down the vial wall; do not shake.
Refrigerate at 2–8°C and use within 30 days of reconstitution.
Research background
DSIP was isolated in 1974 by Monnier and Schoenenberger from dialysate of rabbits in electrically induced slow-wave sleep.
It crosses the blood-brain barrier readily despite its small size, and has been detected endogenously in human plasma, CSF and breast milk.
Research interest has broadened from sleep into stress-hormone regulation, chronic pain models and withdrawal syndromes.
Frequently stacked with
CJC-1295 / Ipamorelin Stack
Synergistic GHRH + GHRP stack for GH-axis research.
COA AvailableThird-party verified
ISO 17025 accredited lab — Batch TR-DSIP-2026-001
HPLC Purity
99.1%
Molecular Weight
✓ Verified
Endotoxin (LAL)
<1.0 EU/mg
Heavy Metals (ICP-MS)
✓ Pass
DSIP — frequently asked
Is DSIP a sedative?
No — the published literature describes it as a neuromodulator that influences sleep architecture, not a GABAergic sedative.
Is DSIP naturally occurring?
Yes. DSIP-like immunoreactivity has been detected endogenously in human plasma, cerebrospinal fluid and breast milk.
Why is the human evidence limited?
Most DSIP work dates from the 1970s–1990s and consists of small clinical series and animal models; it has never gone through modern large-scale trials.
What purity do you guarantee?
≥99% by HPLC with a batch-matched third-party COA.
How fast does it ship?
Orders placed before 2pm ET ship the same business day from Toronto with tracked Canada-wide delivery, typically arriving in 1–3 business days. Cold-pack packaging is used on every shipment.
What if the purity doesn't match the COA?
Every batch is HPLC and mass-spec verified by an ISO 17025 accredited third-party lab, and the batch-matched COA ships with your order. If an independent test comes back below the stated purity, we replace the order or refund it in full.
Is this legal to purchase in Canada?
Yes — these compounds are sold strictly as in-vitro research chemicals for laboratory use. They are not for human or veterinary use, and it is the purchaser's responsibility to comply with applicable federal and provincial regulations.
Ready to add DSIP to your research?
≥99% HPLC-verified, endotoxin and heavy metals tested, batch-matched COA included. Ships same business day from Toronto.
Research Use Only Disclaimer
This product is sold exclusively for in-vitro research and laboratory use only. It is NOT intended for human or veterinary use, consumption, injection, or any clinical application. This product has not been evaluated by Health Canada, the FDA, or any other regulatory authority for safety or efficacy in humans or animals. Trinity makes no medical claims regarding this compound. Researchers must comply with all applicable federal, provincial/state, and local laws regarding the purchase, storage, and use of research compounds. By purchasing this product, you confirm you are a qualified researcher or licensed professional acting within the bounds of applicable law.